Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline-induced cardiac hypertrophy
نویسندگان
چکیده
منابع مشابه
Soluble epoxide hydrolase inhibitor, t-TUCB, protects against myocardial ischaemic injury in rats.
OBJECTIVES To determine the protective role of a soluble epoxide hydrolase(sEH) inhibitor, trans-4-{4-[3-(4-trifluoromethoxyphenyl)-ureido] cyclohexyloxy} benzoic acid (t-TUCB), in isoproterenol (ISO)-induced myocardial ischaemic injury in vivo. METHODS Cardioprotective activity of t-TUCB was studied against ISO-induced myocardial ischaemic injury in male Wistar rats. Cardioprotection was ass...
متن کاملSoluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy.
Pathophysiological cardiac hypertrophy is one of the most common causes of heart failure. Epoxyeicosatrienoic acids, hydrolyzed and degraded by soluble epoxide hydrolase (sEH), can function as endothelium-derived hyperpolarizing factors to induce dilation of coronary arteries and thus are cardioprotective. In this study, we investigated the role of sEH in two rodent models of angiotensin II (An...
متن کاملThe potential of soluble epoxide hydrolase inhibition in the treatment of cardiac hypertrophy.
~:'~: mall molecule inhibitors of soluble .~). 'epoxide hydrolase (sEH) have been shown to reduce blood pressure, inflammation, and pain in a number of mammalian disease models. In fact, an inhibitor of sEH has been moved into clinical trials for the treatment of hypertension. The beneficial effect of sEH inhibition is thought to be due to the role of sEH in the metabolism of anti-inflammatory,...
متن کاملPrevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors.
Sustained cardiac hypertrophy represents one of the most common causes leading to cardiac failure. There is emerging evidence to implicate the involvement of NF-kappaB in the development of cardiac hypertrophy. However, several critical questions remain unanswered. We tested the use of soluble epoxide hydrolase (sEH) inhibitors as a means to enhance the biological activities of epoxyeicosatrien...
متن کاملSoluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension.
In stroke-prone spontaneously hypertensive rats (SHRSP) end-organ damage is markedly accelerated by high-salt (HS) intake. Since epoxyeicosatrienoic acids (EETs) possess vasodepressor and natriuretic activities, we examined whether a soluble epoxide hydrolase (sEH) inhibitor, 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), to inhibit the metabolism of EETs, would protect against pathologic...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2013
ISSN: 0007-1188
DOI: 10.1111/bph.12066